People
myarmush@partners.org
Martin Leon Yarmush, MD, PhD
HST Faculty
- Helen Andrus Benedict Professor of Surgery (Biological Chemistry and Molecular Pharmacology)
Contact Information
- 617-371-4882
Degrees
- MD, PhD
Selected Awards/Societies
- 1982-1983 Edwin R. Gilliland Fellowship, MIT
- 1983-1984 Bert K. Kusserow Fellowship Award, ASAIO
- 1984-1987 National Research Service Award, NCI
- 1985-1993 Lucille P. Markey Scholar Award in Biomedical Science
- 1988-1993 NSF Presidential Young Investigator Award
- 1990-1995 NIH Research Career Development Award
- 1992 Board of Trustees Award for Excellence in Research, Rutgers U
- 1993 Founding Fellow - American Institute of Medical and Biological Engineering
- 1994 Hoechst Celanese Innovative Research Award
- 1995 Helen Andrus Benedict Professorship, Harvard Medical School
- 1996 "Martin L. Yarmush Student Award in Biotechnology", Established, Rutgers U
- 1996 Bernard Revel Memorial Award in Arts & Sciences, Yeshiva U
- 1996-2003 Scientific Advisory Committee, Whitaker Foundation
- 1997-1999 Medical Science Review Committee, Juvenile Diabetes Foundation
- 2004 Award for Programmatic Excellence in Undergraduate Education, Rutgers U
- 2004 External Advisory Board, Tissue Engineering Resource Center, Tufts University
- 2004- Scientific Advisory Board, Vicus Therapeutics, Morristown, NJ
- 2005- Scientific Review Committee, Doris Duke Charitable Foundation, NYC
- 2006 Inducted into the New Jersey High Tech Hall of Fame
- 2006 NIH Career Enhancement Award for Stem Cell Research
- 2006- Scientific Advisory Board, Hurel Corporation, Beverly Hills, CA
- 2006- Chairman & Founding Partner, Molecmo Nanobiotechnologies, Inc., Cambridge, MA
Research Interests
Martin Yarmush is one of the leading investigators in molecular and cellular bioengineering, with seminal contributions to the fields of hepatic and skin tissue engineering, applied immunology, metabolic engineering, and genomics and proteomics. As director of the Center for Engineering in Medicine at the Massachusetts General Hospital, he pursues several research topics:
- BioMEMS: Dynamic cell and tissue microsystems, microscale cellular bioreactors
- Metabolic Engineering: Organ and cell cefatting, stem cell modulation via metabolic means
- Molecular and Nanosystems Bioengineering: Nanoparticles for drug delivery and cancer diagnostics; improved viral vectors for gene therapy; new viral infection treatments
- Neuroengineering: Brain and spinal cord-on-a-chip, Fragile-X Syndrome
- Stem Cell Bioengineering: Differentiation to hepatocytes, pancreatic cells and neural cells
- Tissue Engineering: Bioartificial Liver and Skin, Tissue Models of Macular Degeneration
- Transplantation: New Techniques for Reconditioning Organs
Reference Publications
- Yarmush ML, Berthiaume F. Metabolic Engineering and Human Disease. Nature Biotechnol, 1997; 15: 525-528.
- Le Doux JM, Landazuri N, Yarmush ML, Morgan JR. Complexation of retrovirus with cationic and anionic polymers increases the efficiency of gene transfer. Hum Gene Ther, 2001; 12: 1611-1121.
- Andreadis S, Yarmush ML, Morgan J. Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system. FASEB J, 2001, 15: 898-906.
- Davis HE, Rosinski M, Morgan JR, Yarmush ML. Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation. Biophys J, 2004; 86: 1234-1242.
- Thompson MD, King KR, Wieder KJ, Toner M, Yarmush ML, Jayaraman A. Dynamic gene expression profiling using a microfabricated living cell array. Anal Chem, 2004; 76: 4098-4103.
- Park J, Berthiaume F, Toner M, Yarmush ML, Tilles AW. Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotech Bioeng, 2005; 90: 632-644.
- Nahmias Y, Casali M, Barbe L, Berthiaume F, Yarmush ML. Liver endothelial cells promote LDL-R expression and uptake of HCV-like particles in primary hepatocytes. Hepatol, 2006; 43: 257-265.
- Kane BJ, Zinner MJ, Yarmush ML, Toner M. Liver-Specific Functional Studies in a Microfluidic Array of Primary Mammalian Hepatocytes. Anal Chem, 2006; 78: 4291-8.
- Park JS, Toner M, Yarmush ML, Tilles AW. Microchannel bioreactors for bioartificial liver support. Microfluidics and Nanofluidics, 2006; 2: 525-535.
- Nahmias Y, Kramvis Y, Barbe L, Casali M, Berthiaume F, Yarmush ML. A novel formulation of oxygen-carrying matrix enhances liver-specific function of hepatocytes. FASEB J 2006; 20: 2531-2533.
- King KR, Wang, S, Irimia D, Jayaraman A, Toner M, Yarmush ML. A high-throughput microfluidic real-time gene expression living cell array. Lab on a Chip 2007; 7: 77-85.
- Yang E, Maguire T, Yarmush ML, Berthiaume F, Androulakis IP. Bioinformatics analysis of the early inflammatory response in a rat thermal injury. BMC Bioinformatics 2007; 8: 10
- Banta S, Megeed Z, Casali M, Rege K, Yarmush ML. Engineering protein and peptide building blocks for nanotechnology. J Nanosci Nanotechnol 2007; 7: 387-401.
- Nagrath D, Avila-Elchiver M, Yarmush ML. Integrated Energy and Flux Balance Based Multiobjective Framework for Large-Scale Metabolic Networks. Ann Biomed Eng 2007; 35: 863-885.
- Maguire T, Davidovich AE, Wallenstein EJ, Schloss R, Yarmush ML. Control of hepatic differentiation via cellular aggregation in an alginate microenvironment. Biotechnol Bioeng (in press)
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