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HST's educational and research activities are conducted on the campuses of Harvard Medical School in Boston, MIT in Cambridge, and at the various Harvard-affiliated teaching hospitals and research centers in the Boston area.

There are two HST headquarters offices. One office is located at the MIT campus in Cambridge in the Whitaker College Building (E25), room E25-519. The another office, the MD Curriculum office, is located at the Harvard Medical School campus in Boston in the Daniel C. Tosteson Medical Education Center (MEC), room 213.
 

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